Course Website Locator: epi244-01

Harvard School of Public Health

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Spring 1 2010

Dr. S. L. Santangelo, Dr. D. Pauls
2.5 Credits
Offered alternate years. Offered 2009-2010.
Lectures. One 3-hour session each week.

Designed to introduce students to classical and current research methodology for genetic epidemiologic studies of complex (non-Mendelian) disorders using examples drawn from the psychiatric genetics literature. Topics include issues in phenotype definition, design and analysis of family, twin and adoption studies, segregation analysis, linkage analysis, and association study methods. Students will gain direct experience in carrying out linkage and association analyses using different approaches and analytic packages. Laboratory sessions will be devoted to gene-finding methods and discussion of the technical details of executing the relevant computer programs and interpretation of results. This is one of the courses on the psychiatric epidemiology track, but it may also be of interest to students interested in methods for studying any disorders with complex genetic inheritance.

Course Activities: Lectures, class discussion, homework assignments, labs devoted to computer analyses of data, interpretation, oral or written presentation of results of data analysis.

Course Notes: 1, 5: Students should have an understanding of basic epidemiologic research methods, introductory biostatistics and probability; enrollment limited to 25 students.

Course evaluations are an important method for feedback on the quality of course offerings. The submission of a course evaluation is a requirement for this course. Your grade for the course will be made available only after you have submitted responses to at least the first three questions of the on-line evaluation for this course.

Spring 2 2008

Dr. S. L. Santangelo, Dr. P. Van Eerdewegh
2.5 Credits
Course offered 2005-2006
Lectures, labs. One 3-hour class and one lab.

Designed to introduce students to classical and current research methodology for genetic epidemiologic studies of complex (non-Mendelian) disorders using examples drawn from the psychiatric genetics literature. Topics include issues in phenotype definition, design and analysis of family, twin and adoption studies, segregation analysis, linkage analysis, and association study methods. Students will gain direct experience in carrying out linkage and association analyses using different approaches and analytic packages. Laboratory sessions will be devoted to gene-finding methods and discussion of the technical details of executing the relevant computer programs and interpretation of results. This is one of the courses on the psychiatric epidemiology track, but it may also be of interest to students interested in methods for studying any disorders with complex genetic inheritance.
Course Activities: Lectures, class discussion, homework assignments, labs devoted to computer analyses of data, interpretation, oral or written presentation of results of data analysis.
Course Notes: Students should have an understanding of basic epidemiologic research methods, introductory biostatistics and probability; BIO227or signature of instructor required; enrollment limited to 25 students.



Course evaluations are an important method for feedback on the quality of course offerings. The submission of a course evaluation is a requirement for this course. Your grade for the course will be made available only after you have submitted responses to at least the first three questions of the on-line evaluation for this course.

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