Course Website Locator: bio276-01

Harvard T.H. Chan School of Public Health

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Fall 2007

Dr. C. Mehta
2.5 credits
Course offered 2006-2007; offered alternate years
Lectures. One 2-hour session each week.

This course will cover the basic theory underlying the design and interim monitoring of group sequential clinical trials and will illustrate the theory with examples of real clinical trials. Topics include: distribution theory for stochastic processes with independent increments; the recursive integration algorithm; stopping boundaries and error spending functions; maximum information trials; conditional power and stochastic curtailment; repeated confidence intervals; inference following group sequential testing; sample size re-estimation; more general adaptive
designs. Software support for this course will be provided by East software.
Course Note: BIO 230 or signature of instructor required. (5.06)

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